AI-generated digital twins for science
HORIZON-INFRA-2025-01-TECH-04
Funding Amount
€8.0M - €10.0M
Deadline
18/09/2025
Eligible Organization Types
Non-profit, Private Business, Research Institution, Public Institution
Trusted by
What is the AI-generated digital twins for science Call?
Grant Description
This call supports research and innovation actions to develop and demonstrate generative artificial intelligence powered digital twins of complex real-world systems for European research infrastructures. Projects will advance modelling and simulation methods, data fusion and workflow execution, and enable non-technical decision makers to express scenarios. Funded activities include creation or enhancement of digital twins in key sectors, demonstration in relevant environments, development of bes...
Required Results for Successful Funding
Expected Outcomes
Project results are expected to deliver:
• Demonstrations of innovative use of AI (aligned with Gen AI 4 EU and Apply AI strategy) for setting up and managing highly complex modelling and simulation activities across diverse RIs.
• New best practices and guidelines for AI-driven model generation, digital twin creation, simulation and simulation-observation data fusion.
• Emergence of novel AI-powered applications and use cases for digital twins, supporting transformative research methods and advanced future services in key sectors.
• Demonstrations of innovative use of AI (aligned with Gen AI 4 EU and Apply AI strategy) for setting up and managing highly complex modelling and simulation activities across diverse RIs.
• New best practices and guidelines for AI-driven model generation, digital twin creation, simulation and simulation-observation data fusion.
• Emergence of novel AI-powered applications and use cases for digital twins, supporting transformative research methods and advanced future services in key sectors.
Funded areas
Scope Requirements
Proposals must:
1. Use generative AI (in line with Gen AI 4 EU and Apply AI strategy) to create or enhance digital twins of complex systems in key impact sectors (e.g. healthcare including mental health; transportation; agriculture; environment; manufacturing; Clean Industrial Deal fields).
2. Base solutions on existing generative AI model baselines, defining required data fusions, visualisations and end-to-end workflow execution.
3. Advance RI capabilities by opening new research areas and broader user communities (industrial, scientific, policy), addressing EU policy objectives and socio-economic challenges.
4. Demonstrate solutions, at least in part, in a relevant environment conducive to sustainable production, including a cost estimate for operations.
5. Leverage recent advances in AI (Foundation Models such as LLMs; Federated Learning) and connect to EU AI initiatives (European AI factories, AI-on-demand).
6. For Earth-systems and socio-economic impact digital twins, adhere to Destination Earth standards and ensure interoperability with the existing Destination Earth system.
7. Cover all of the following required aspects:
• Setup of complex modelling and digital twin environments using generative AI.
• Data-driven approach with demonstration in at least three distinct application scenarios.
• Mechanisms for non-technical decision-makers to define scenarios for simulation.
• Validation of AI trustworthiness/reliability and open communication of AI use.
8. Additionally address some or all of:
• Best practices for AI-generated digital twin setup.
• Contributions to European AI factories’ capabilities.
• Cross-domain validation (solutions operating in at least two scientific domains).
9. Exploit synergies with existing Horizon Europe RIA/CSA projects (e.g. Gen AI 4 EU central hub) and emerging infrastructures (EuroHPC, AI-on-demand).
10. For energy-intensive industrial transition topics, plan close cooperation with the EC Joint Research Centre (JRC).
1. Use generative AI (in line with Gen AI 4 EU and Apply AI strategy) to create or enhance digital twins of complex systems in key impact sectors (e.g. healthcare including mental health; transportation; agriculture; environment; manufacturing; Clean Industrial Deal fields).
2. Base solutions on existing generative AI model baselines, defining required data fusions, visualisations and end-to-end workflow execution.
3. Advance RI capabilities by opening new research areas and broader user communities (industrial, scientific, policy), addressing EU policy objectives and socio-economic challenges.
4. Demonstrate solutions, at least in part, in a relevant environment conducive to sustainable production, including a cost estimate for operations.
5. Leverage recent advances in AI (Foundation Models such as LLMs; Federated Learning) and connect to EU AI initiatives (European AI factories, AI-on-demand).
6. For Earth-systems and socio-economic impact digital twins, adhere to Destination Earth standards and ensure interoperability with the existing Destination Earth system.
7. Cover all of the following required aspects:
• Setup of complex modelling and digital twin environments using generative AI.
• Data-driven approach with demonstration in at least three distinct application scenarios.
• Mechanisms for non-technical decision-makers to define scenarios for simulation.
• Validation of AI trustworthiness/reliability and open communication of AI use.
8. Additionally address some or all of:
• Best practices for AI-generated digital twin setup.
• Contributions to European AI factories’ capabilities.
• Cross-domain validation (solutions operating in at least two scientific domains).
9. Exploit synergies with existing Horizon Europe RIA/CSA projects (e.g. Gen AI 4 EU central hub) and emerging infrastructures (EuroHPC, AI-on-demand).
10. For energy-intensive industrial transition topics, plan close cooperation with the EC Joint Research Centre (JRC).
Additional Conditions for Applicants
Special Conditions
Admissibility and eligibility conditions:
• Page limits and layout governed by Horizon Europe Work Programme General Annexes (Annex A & E) and Part B of the Application Form.
• Eligible countries as in Annex B; non-EU/Associated country rules apply.
• Protection of European communication networks (Annex B restrictions).
• Financial and operational capacity and exclusion criteria (Annex C).
• Evaluation and award: criteria, scoring and thresholds (Annex D); submission and evaluation process, timeline (Annex F).
• Lump sum funding as per 7 July 2021 Decision; legal and financial setup in Annex G.
• Use of HORIZON-AG-LS (lump sum) grant model and the standard HE RIA application, evaluation and MGA templates.
• Proposals must be submitted via the Funding & Tenders Portal by 18 Sept 2025, 17:00 Brussels time.
• Earth-systems digital twins must comply with Destination Earth standards.
• Energy-intensive industrial transition proposals should coordinate with JRC.
• Participation may trigger additional national provisions for non-associated countries.
• Page limits and layout governed by Horizon Europe Work Programme General Annexes (Annex A & E) and Part B of the Application Form.
• Eligible countries as in Annex B; non-EU/Associated country rules apply.
• Protection of European communication networks (Annex B restrictions).
• Financial and operational capacity and exclusion criteria (Annex C).
• Evaluation and award: criteria, scoring and thresholds (Annex D); submission and evaluation process, timeline (Annex F).
• Lump sum funding as per 7 July 2021 Decision; legal and financial setup in Annex G.
• Use of HORIZON-AG-LS (lump sum) grant model and the standard HE RIA application, evaluation and MGA templates.
• Proposals must be submitted via the Funding & Tenders Portal by 18 Sept 2025, 17:00 Brussels time.
• Earth-systems digital twins must comply with Destination Earth standards.
• Energy-intensive industrial transition proposals should coordinate with JRC.
• Participation may trigger additional national provisions for non-associated countries.
Important dates
Open from: 06/05/2025
Deadline:18/09/2025
Application period has ended
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